Alzheimer’s Trial Posts Positive Data; How Coronavirus Can Attack the Brain

Phase II trial data showed that sumifilam, an investigational drug that binds to filamin A, significantly improved a panel of Alzheimer’s biomarkers and showed trends toward cognitive improvement in patients with mild-to-moderate Alzheimer’s disease, Cassava Sciences announced.

Blackout drinking raised the risk of dementia, even for moderate drinkers. (JAMA Network Open)

The NIH’s National Institute on Aging funded four new exploratory Alzheimer’s Disease Research Centers to expand dementia research in underrepresented populations, including African Americans, Native Americans, and people living in rural communities.

A neurologist writes about her first house call during the COVID-19 pandemic… (Neurology)

…while another tells what happened when he was deployed to the COVID unit. (Neurology)

In a pre-print study, researchers looked at three ways at how SARS-CoV-2 may infect the brain: in brain tissue from deceased COVID-19 patients, in a mouse model, and in human brain organoids. (bioRxiv)

During the pandemic, epilepsy patients with tumor-related seizures, drug-resistant epilepsy, insomnia, and economic difficulties had a higher risk of increased seizure frequency, a survey showed. (Acta Neurologica Scandinavica)

Will “coronasomnia” have profound effects on public health? (Washington Post)

Pregnancy was linked to delayed onset of clinically isolated syndrome, the first symptoms that may signal multiple sclerosis (MS). (JAMA Neurology)

The narcolepsy drug modafinil (Provigil), also used in MS-related fatigue and to treat attention-deficit/hyperactivity disorder, was not significantly associated with increased risk of major malformations when used during early pregnancy. (JAMA)

Simvastatin (Zocor) failed to slow Parkinson’s disease in the PD-STAT trial, the University of Plymouth in England announced.

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow